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Absorbed mesalazine undergoes presystemic N-acetylation in intestinal mucosa and the liver

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The pathogenic role of copper is context-dependent and exhibits a U-shaped risk curve

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In this review, we have discussed the potential mechanisms of renal tubular injury in DKD, including hyperglycemia, lipid accumulation, oxidative stress, hypoxia, RAAS, ER stress, inflammation, EMT and programmed cell death